Protective vascular and myocardial effects of adiponectin
نویسندگان
چکیده
منابع مشابه
Inflammation and Vascular Calcification Causing Effects of Oxidized HDL are Attenuated by Adiponectin in Human Vascular Smooth Muscle Cells
The role of oxidized high-density lipoprotein (oxHDL) and the protective effects of adiponectin in terms of vascular calcification is not well established. This study was conducted to investigate the effects of oxHDL with regards to inflammation and vascular calcification and to determine the protective role of adiponectin in attenuating the detrimental effects of oxHDL. Cell viability, mineral...
متن کاملThe protective role of adiponectin in pulmonary vascular disease.
ADIPONECTIN (APN), a 30-kDa multimeric protein exclusively produced by fat cells, reverses insulin resistance (IR) and is independently associated with a reduced risk of type 2 diabetes in apparently healthy individuals (10). However, in IR states such as obesity and type 2 diabetes, its expression and circulating levels are decreased. Low APN and high proinflammatory C-reactive protein and IL-...
متن کاملVascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention.
Adiponectin is a major adipocyte-secreted adipokine abundantly present in the circulation as three distinct oligomeric complexes. In addition to its role as an insulin sensitizer, mounting evidence suggests that adiponectin is an important player in maintaining vascular homoeostasis. Numerous epidemiological studies based on different ethnic groups have identified adiponectin deficiency (hypoad...
متن کاملThe vascular protective effects of estrogen.
There is now strong epidemiological evidence that estrogen replacement therapy has a protective effect in postmenopausal women. The cardiovascular protective action of estrogen is reported to be mediated indirectly by an effect on lipoprotein metabolism and by a direct effect on the vessel wall itself. Estrogen is active both in vascular smooth muscle and endothelium. Functionally competent est...
متن کاملProtective effects of adenosine in myocardial ischemia.
Adenosine is released from the myocardium in response to a decrease in the oxygen supply/demand ratio, as is seen in myocardial ischemia; its protective role is manifested by coronary and collateral vessel vasodilation that increase oxygen supply and by multiple effects that act in concert to decrease myocardial oxygen demand (i.e., negative inotropism, chronotropism, and dromotropism). During ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Clinical Practice Cardiovascular Medicine
سال: 2008
ISSN: 1743-4297,1743-4300
DOI: 10.1038/ncpcardio1398